Foreword
This document is drafted in accordance with the provisions of GB/T 1.1-2020 "Guidelines for standardization work Part 1: Structure and drafting rules of standardization documents".
Please note that some of the contents of this document may involve patents. The issuer of this document does not assume responsibility for identifying patents. This document is presented by the Ministry of Emergency Management of the People's Republic of China.
This document is attributed to the Chemical Safety Sub-Technical Committee of the National Technical Committee for Standardization of Work Safety (SAC/TC 288/SC 3).
1 Scope
This document specifies the requirements for fine chemical reaction safety risk assessment, assessment basis conditions ﹑ data testing and acquisition methods, assessment criteria and assessment report requirements.
This document applies to the safety risk assessment of intermittent, semi-intermittent and continuous kettle reactions of fine chemicals.
2 Normative references
There are no normative references in this document.
3 Terminology and Definitions
The following terms and definitions are applicable to this document.
4 Assessment requirements
4.1 Evaluation objects
4.1.1 owl domestic first use and put into industrial production of new processes, new formulations, the first introduced from abroad and has not been the reaction safety risk assessment process.
4.1.2 The existing process route, process parameters or device capacity changes and has not been carried out reaction safety risk assessment of the process. 4.1.3 Because of the reaction process problems have occurred in the production safety accident process.
4.1.4 belonging to the fine chemical industry focus on the supervision of dangerous chemical processes and metal-organic synthesis reactions (including Grignard reaction).
4.1.5 New fine chemical enterprises should complete reaction safety risk assessment before preparing feasibility study report or project proposal. 4.2 Test and evaluation content
4.2.1 Reaction safety risk assessment should include material decomposition heat assessment, uncontrolled reaction severity assessment, uncontrolled reaction possibility assessment, uncontrolled reaction risk acceptability assessment and reaction process hazard assessment.
4.2.2 Reaction safety risk assessment should be raw materials, catalysts, intermediate products, products, by-products, waste, and distillation, fractional distillation process involving the thermal stability of the materials tested, the chemical reaction process to carry out thermodynamic and kinetic research testing and analysis.
4.2.3 involving nitrification, chlorination, fluorination, diazotization, peroxidation process of the fine chemical production plant should complete the entire production process of the relevant product reaction safety risk assessment.
5 Assessment of basic conditions
5.1 Material information
Reaction safety risk assessment requires material information, including but not limited to raw materials, catalysts, intermediate products, products, by-products, waste, and distillation, fractionation process involving the relevant materials (including but not limited to pure substances and mixtures of materials) of the main components, composition, content and source.
5.2 Process information
The process information required for reaction safety risk assessment, including reaction temperature, reaction pressure, material ratio, charging rate, charging time, holding time, heating rate, and precautions.
5.3 Analysis methods
Reaction safety risk assessment should be complemented by the necessary analysis of the process involving raw materials, intermediates and products for qualitative and quantitative analysis.
5.4 Process devices
The reaction safety risk assessment should provide the necessary information about the process equipment, including but not limited to the reaction pressure, reactor volume, design parameters, feeding coefficients, reactor specifications/models, and heat transfer media information.
6 Data testing and acquisition method
6.1 Heat of material decomposition
6.1.1 Through the reaction risk study, we obtain the starting exothermic decomposition temperature, heat of decomposition and other thermal stability data of the material, and use the obtained data as the basis to evaluate the heat of decomposition of the material.
6.1.2 material thermal stability research to take joint test research means, including but not limited to differential scanning calorimetry, pressure tracking differential scanning calorimetry, rapid screening calorimetry, adiabatic calorimetry, trace heat, should be based on material characteristics of milligram to gram level test, test methods see GB/T 22232, GB/T 13464 and SN/T 3078.1.
6.1.3 For homogeneous materials, the starting exothermic decomposition temperature is the lowest value of the joint test results in 6.1.2, and the heat of decomposition is the highest value of the joint test results in 6.1.2; among them, the decomposition is intense, the heat of decomposition of large materials, adiabatic test is difficult to obtain the complete heat of decomposition data, take the milligram test results.
6.1.4 For the non-homogeneous mixture, the gram level test of the joint test in 6.1.2 the test device should have the function of mixing for the non-homogeneous materials, and the starting exothermic decomposition temperature should be the lowest value of the joint test result of gram level, and the decomposition heat should be the highest value of the joint test result of gram level.
7 Evaluation criteria
7.1 According to the heat of decomposition of materials to assess the explosion risk of materials, according to the adiabatic temperature rise to assess the severity of uncontrolled reaction, according to the maximum reaction rate to assess the possibility of uncontrolled reaction, combined with the relevant temperature parameters for process risk assessment, to determine the level of risk of the reaction process.
7.2 The heat of decomposition was evaluated by using the heat of decomposition of materials, and the evaluation criteria were shown in Table 1.
8 Assessment report
8.1 The content of the reaction safety risk assessment report should at least include the test content, assessment content, assessment conclusions and recommended measures.
Appendix A (informative) Example of the main contents of the fine chemical reaction safety risk assessment report
Bibliography
Foreword
1 Scope
2 Normative references
3 Terminology and Definitions
4 Assessment requirements
5 Assessment of basic conditions
6 Data testing and acquisition method
7 Evaluation criteria
8 Assessment report
Bibliography
